Host Defense at the Ocular Surface
نویسندگان
چکیده
منابع مشابه
Microbes at the host surface
The human body encounters pathogenic bacteria every day although establishment of infections after such contacts is rare. The skin and mucosal surfaces, which comprise the barrier between the body and the external milieu, are the first lines of defense, and colonization of these surfaces is normally the first step in bacterial disease. As a physical barrier, the skin is reinforced by dry, sligh...
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The ocular surface, which is among the most accessible and vulnerable tissues in mammals, is protected by a complex tear film composed of lipid, aqueous and mucin layers. In spite of its importance, the molecular nature of the mucin contribution remains uncertain. Since membrane mucins have been implicated in the protection of other epithelia, we have analysed rat corneal and conjunctival tissu...
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Autophagy is a fundamental cellular process used for the turnover and recycling of cytosolic components and damaged organelles. Originally characterized as a response to cellular stress, it now is well established that autophagy also is used as a defensive mechanism to combat the infection of host cells by intracellular pathogens. However, although this defensive strategy does limit the prolife...
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Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon. In addition, we tested the primate glands of Moll with antibodies against antimicrobial proteins, cytoskeletal proteins and the androgen receptor. The glands of Moll d...
متن کاملThe spectrum of antimicrobial peptide expression at the ocular surface.
PURPOSE Antimicrobial peptides are the eukaryotic analogues of antibiotics. In addition to their antimicrobial activity, these peptides can signal to host cells and are therefore intermediaries between the innate and adaptive immune systems. Results in a prior study showed that beta-defensins-1 and -2 are made by ocular surface epithelial cells. In the present study, a survey was made of antimi...
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ژورنال
عنوان ژورنال: International Reviews of Immunology
سال: 2013
ISSN: 0883-0185,1563-5244
DOI: 10.3109/08830185.2012.749400